BioNex Solutions Nanodrop II & Nanodrop Express

BioNex Solutions Nanodrop II & Nanodrop Express

For a complete high-throughput solution for low-volume, high-precision pipetting, try the 8-channel Nanodrop II or the 16-channel Nanodrop Express.

Each system has interchangeable, fixed-tip heads (1×8 or 2×4 configurations for the Nanodrop II and 1×16 or 2×8 configurations for the Nanodrop Express) and comes with two plate positions that enable applications such as assay miniaturization, DNA normalization, method development, PCR and NGS reaction setup, or protein crystallography.

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Description

The Nanodrop technology aspirates and dispenses a broad range of liquids, including DMSO, and features the Nanobuilder software system that enables a wide range of applications and data manipulation. This patented technology isolates the solenoid dispense actuators from the sample path to assure long life and easy, low- cost maintenance – even with regular use of difficult suspensions such as proteins, cells and YOx beads.

Key Features and Benefits

  • Sample transfer and bulk reagent addition on the same platform
  • Aspirate and dispense with individual channel volume control
  • Interchangeable 1×8 to 2×4 head; or, 1×16 to 2×8 heads
  • Micro solenoid valves for fast, precise low-volume applications and mixing
  • Exceptional dynamic range (nanoliter to milliliter)
  • Valve-free fluid path for outstanding reliability
  • FEP, SS, sapphire wetted parts compatible with commonly used solvents
  • 96-, 384- and 1536-well plate formats, irregular and flat plate formats supported
  • Deep well and crystallography plates supported
  • Easy to program, easy to automate
  • Simple cleaning and maintenance

Typical Applications

  • PCR template and cocktail additions
  • DNA normalization
  • Assay miniaturization
  • Serial dilution
  • Cell plating
  • Sample transfer
  • Bulk reagent addition
  • Protein crystallography screens
  • MALDI plate spotting

Performance Specifications

Dispense Range

  • Microsolenoids: 0.1 – 800 uL
  • 500 uL syringe: 5-500 uL
  • 1000 uL syringe: 5-1000 uL

Aspirate Range

  • 500 uL syringe: 0-500 uL
  • 1000 uL syringe: 0-1000 uL

Dispense Precision

  • Less than 10% at 100 nL
  • Less than 7% at 200 nL
  • Less than 5% at 1 uL

Residual Volume

  • < 3ul per channel

Advantages of Non-Contact Dispensing

Non-contact liquid handling relies on the combined use of rapidly actuated solenoid dispense valves, a controlled pressurized liquid source, and flow path control via hybrid valves. The speed and energy of the fluid displacement enables the surface tension of the liquid to break as it leaves the orifice, eliminating the need for a touch-off.  The lack of a touch-off step in the dispense eliminates the variability issues associated with touching off.

An important added benefit of non-contact dispensing is speed — the non-contact technique allows the delivery nozzle to accurately deliver the droplet above the target well and rapidly move to the next well. With the non-contact technique dispensing becomes independent of the substrate, eliminating many of the reproducibility problems associated with motion control. Plate processing times fall dramatically. Using non-contact dispensing it is possible to deliver to all wells of a 96 well plate in approximately 5 seconds, 384 wells in approximately 7 seconds, and 1536 wells in approximately 14 seconds.

Resources

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