Cell line development solutions with automated clone screening
The ClonePix™ 2 Mammalian Colony Picker is a fully automated system for the selection of high-value clones used in antibody discovery and cell line development. Hybridoma, CHO cells, and other cell types are imaged and selected based on user-defined parameters. Plate handling, barcode reading, and picking are all fully integrated. All data, including images, are saved for downstream analysis. The picker increases the probability of finding optimally produced cell lines and significantly reduces time and labour.
Multiple detection methods
White light identifies and measures clone morphology, size and proximity. Fluorescence indicates expression level and/or specificity. Up to five fluorescent filters are available for multiplexing.
A host of sterility features and options including a UV light process for sanitising the interior of the instrument, as well as pin washing and halogen drying are standard.
Integrated plate storage
Includes two storage stacks for source and destination plates, each with a capacity of 10 plates.
Discrete colony formation
Semi-solid CloneMedia™ encourages single cells to grow into discreet colonies and allows for ease of plating. The media allows for a higher density of clones to be screened.
Animal-free media and reagents
Chemically defined and animal-free, CloneMedia cell-culture media is optimised to increase productivity and aid in visualising secreted antibodies when used with the CloneDetect™ detection agent.
Custom automation options*
FortéBio’s Advanced Workflow Engineering Solutions team can customise the monoclonality system and offer added services such as integrated verification of monoclonality.