Solutions for the Medicinal Cannabis industry
Simplify workflows with Gilson CPC Systems
– The right choice for cannabinoid purification
Improved cannabinoid yield and
zero sample loss at less cost
Gilson’s line of VERITY Centrifugal Partition Chromatography (CPC) instruments deliver high yielding, efficient and scalable extraction and purification solutions to the medicinal cannabis industry. Being a silica-free technology makes CPC very cost-effective, and it’s dramatically reduced solvent use results in a more environmentally-friendly, green extraction method.
Easy scale-up with fully integrated systems providing high yields, high purity, high speed and minimal product loss. Future proof your process with the flexibility for research, pilot and industrial scale production on a GMP compatible system.
CPC being a silica free technology means there is no need to replace columns or recycle silica. CPC’s capacity to recycle solvent saves you up to 80% on solvent use compared to solid-phase extraction methods.
With over 40 years of experience in preparative and industrial chromatography, Gilson offers expertise and worldwide services to support you. From lab to industrial scale, Gilson have supported hundreds of cannabis scientists and technicians around the world with purification services and systems.
The technology behind CPC purification
Chromatographic purification of natural compounds presents many challenges to scientists because of the complex nature of the starting matrices that are used in the process. Rather uniquely, CPC uses both liquid stationary and mobile phases and as such can handle heavily contaminated, complex starting materials such as direct extracts from many biological sources.
Separation is based on liquid-liquid partitioning:
- Uses 2 immiscible liquid phases
- The stationary phase is contained by centrifugal force
- The mobile phase pumps through the stationary phase
- Compounds are separated through their relative affinity to each liquid phase
For more information about CPC technology:
Cost effective and scalable solutions for obtaining high purity cannabinoids from a crude extract
From lab to industrial scale, Gilson offers complete cannabinoid purification solutions
Complete cannabinoid purification solutions provider
Gilson don’t just develop market leading technology. Their dedicated and experienced teams are available to make sure that you get the best from their systems with a range of purification services including engineering design, application development, feasibility and scale-up studies, qualification support, and installation services as part of operational ramp-up.
Solve Scientific as Gilson’s exclusive instruments representative, have local staff each with over 25 years’ experience working with Gilson. Together, with the backing of a global network of CPC Application Specialists, CPC Service & Validation Engineers, and factory support from Gilson’s CPC Centres of Excellence, Solve Scientific can uniquely provide Australian and NZ customers easily accessible local expertise with applications tailored to serve business strategies, and service and support to keep instruments running at peak performance.
From lab to industrial scale, Gilson has supported hundreds of cannabis scientists and technicians around the world with their purification services and systems.
Assess the potential
of your sample
Perform Proof of Concept
up to process scale
Optimise your own
How we can |
1. Screen available
4. Perform the intensification
and scale-up studies
7. Assist with the organisation
of the production process
2. Develop methods
optimised for your sample
5. Produce up to kilograms
of pure molecules
(as raw material or for trials)
8. Train your teams at a
Gilson Purification centre
3. Produce up to several grams
of pure molecules
(as a standard or for trials)
6. Review the economics
and risks related to
large scale production
9. Provide support and equipment
through the operational
ramp up stage
Interested in learning more?
Whether you are at the beginning of your journey or already at production stage, contact us with any questions you might have or to learn more about Gilson cannabis purification products, systems, and services.
Leverage global expertise with local service and support to accelerate your cannabis purification project outcomes
Purification of Cannabidiol from Cannabis sativa
Cannabidiol (CBD) is a non-psychotropic cannabinoid from the Cannabis sativa L. (Cannabaceae) plant. Researchers have shown that CBD’s medicinal properties may be of use for treating a variety of conditions including pain, inflammation, epilepsy, and cancer. Changes in the legal status of cannabis for medical use, along with the increasing number of therapeutic applications for CBD, has resulted in rapidly growing demand for highly pure CBD. As such, it is crucial to develop standardised CBD products free of unwanted components to ensure patient safety. CBD manufacturers will require efficient, cost-effective methods that can produce high yields of impurity-free products.
This article describes a rapid and reproducible method for large-scale purification of pure CBD using CPC.
Single-step purification of THC, CBD, CBN, CBG and minor cannabinoids
CPC is recognised as the preferred technology for the purification of high quality Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) for the pharmaceutical and food supplement markets. The objective of this app note was to test the high selectivity of CPC and assess its capability to purify a set of key compounds (THC, CBD, CBN and CBG) and enrich several minor cannabinoids (CBDV, CBCV and CBC).
Multi-ton processing of full spectrum cannabis oil for THC remediation
Δ-9-tetrahydrocannabinol (THC) content in cannabis products, such as food supplements, vapes, or medicinal matrices, is strictly regulated in most countries worldwide. This has fuelled demand for broad spectrum THC-free oil, and spurred interest in THC remediation technologies applicable at industrial scale level. CPC is a preferred technology with natural product purification due to its ability to extract, remove or purify a target compound without denaturing or losing other compounds present with it in the sample.
This application note demonstrates the added value of CPC for THC remediation of multiple tons of full-spectrum oil.
About Solve Scientific
Solve Scientific caters to the Australian and New Zealand scientific market with high-quality product and innovative technologies. In close partnership with our suppliers our role is delivering premium local support in enabling our customer’s results.