Applications

Cell Line Development

Solutions to accelerate the cell line development workflow with technologies for:

  • Single cell seeding and monoclonality assurance
  • Bioprocess titre and impurity testing, process development and QC

Enhancing cell line development workflows with our partners Solentim and FortéBio

Solentim provides streamlined workflows for the creation, isolation and characterisation of high value cells.  For over a decade, Solentim has enabled workflows, validated through Regulatory submission, in key cell therapy areas including cell line development, vaccines, stem cells and gene therapy.  Solentim’s unrivalled VIPS™ and Cell Metric®  instruments work to provide high efficiency single cell seeding and to capture evidence and provide assurance of clonality.

FortéBio’s Octet systems, based on biolayer interferometry (BLI) technology enable label-free biologic characterisation for bioprocess titre and impurity testing, process development and quality control.  BLI characterisation of biologics provides critical information for specificity and affinity of biomolecular interactions to monitoring concentration and Critical Quality Attributes during cell line development and bioprocessing workflows.

Monoclonality assurance tools streamlining CLD workflows

Smarter workflows for future medicines

Solentim accelerates cell line workflow timelines from upstream development through scale-up to production of new biological therapies.  From vector design and host cell selection prior to transfection, single-cell cloning and colony outgrowth right through to the establishment of the Master Cell Bank, Solentim technologies provide the evidence for credible IND submissions.

Solentim’s platforms and reagents support the following CLD workflows:

Thumb Biologics

Biolayer interferometry (BLI) advancing CLD workflows

Industry standards for label-free analysis of biomolecular interactions

BLI characterisation of biologics provides critical information for specificity and affinity of biomolecular interactions to monitoring concentration and Critical Quality Attributes during cell line development and bioprocessing workflows.

FortéBio’s Octet systems accelerate the cell line development workflow by providing fast, reliable quantitation, even in crude samples.  Rapidly screen clone libraries to isolate high producing clones, monitor product quality and titre through the manufacture process, and qualify your biologic lot-to-lot.  With Octets, you can perform:

About Solve Scientific

Solve Scientific caters to the Australian and New Zealand scientific market with high-quality product and innovative technologies. In close partnership with our suppliers our role is delivering premium local support in enabling our customer’s results.

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