PLC purification systems

All-in-one preparative HPLC, Flash chromatography and CPC

Flexible and high performance
liquid chromatography

With the capability to purify compounds by preparative HPLC, CPC and flash chromatography on the same instrument, Gilson’s PLC purification systems simplify and streamline compound purification.  These customisable instruments are available in simple configurations for basic applications, but with a wide range of upgrade options to meet your lab’s demands.

Classic HPLC to flash to CPC

Easily switch from preparative to flash chromatography with a simple column change.  Connect to a Gilson CPC system for complete, fully automated CPC purification.

Smart design for maximised performance

These compact systems feature UV/VIS detection, an integrated pumping system, fraction collector, touchscreen control, and Gilson Glider Prep software.

Easy to use

PLC systems feature an intuitive touchscreen interface for easy method writing and modifying of parameters.


Increase your purification throughput

PLC 2050 and PLC 2250 purification systems with Autosampler are configured with a VERITY® GX-241 Liquid Handler and VERITY 4020 Single Syringe Pump for automated sample injections for increased throughput.  These systems allow you to queue samples and create multiple, unattended runs.

Versatile to perform advanced purification protocols

PLC systems contain a variable dynamic mixing chamber and feature two or four independent solvent inlets for binary or quaternary gradients.

Detection options

PLC systems include a conductivity / pH monitor and four-wavelength UV/VIS detection, with an optional upgrade to a diode array detector (DAD) or evaporative light scattering detection (ELSD). 

Large capacity for a variety of applications

PLC systems have a large fraction capacity, containing a three-rack fraction collector with unlimited collection cycles.  These systems support purification from 10 – 100 mm HPLC columns, 100 – 1000 mL CPC columns and 2.5 g – 1.2 Kg flash cartridges.

Intelligent integrated pumping

PLC systems feature a dual reciprocating pump technology, with a built-in automatic injection valve.

Download brochures for more information:

PLC Purification Systems
VERITY Purification Systems


PLC 2050
Low-capacity system

Compact system that is well-suited for research scale purifications

PLC 2250
Moderate-capacity system

Versatile purification system with higher-throughput and capacity

PLC 2500
High-capacity system

With a flow rate of up to 500 mL/min, perform large scale purifications with ease


PLC 2050 PLC 2250 PLC 2500
Flow rate range 1 - 50 mL/min 5 - 250 mL/min 10 - 500 mL/min
Maximum pressure 300 bar 230 bar 110 bar
Preparative HPLC column diameter 10 – 30 mm 10 – 50 mm 20 – 100 mm
Flash chromatography cartridges 2.5 – 70 g 10 – 600 g up to 1.2 kg
Compatible CPC column sizes
100 mL
250 mL
1000 mL



* PRO model columns with greater injection capacity

About Solve Scientific

Solve Scientific caters to the Australian and New Zealand scientific market with high-quality product and innovative technologies. In close partnership with our suppliers our role is delivering premium local support in enabling our customer’s results.

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