SOLENTIM

CELL METRIC SYSTEMS

BENCHTOP HIGH-RESOLUTION WHOLE WELL IMAGING

Providing dedicated, purpose-designed, high-resolution whole-well imaging for daily recording of clonal outgrowth in CLD

THE TRUSTED STANDARD FOR CLONAL ASSURANCE

The Cell Metric® instrument range are high contrast imagers designed for single cell imaging, identification and clonal outgrowth characterisation.  Cell Metric systems capture and record crucial evidence, whole well image of the single cell at day 0 and daily imaging thereafter, all wrapped up in a clonality report defining best practice for Master Cell Bank production.  The Cell Metric X series further simplifies clonal assurance with artificial intelligence-based Automated Evidence of Clonality (AEC).

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Clonal assurance on day 0 

Cell Metric set the standard for high-contrast imaging.  Cell Metric X raises the bar, delivering faster, easier clonality verification on day 0 to accelerate your path to IND submission — with zero compromise in quality.

Simplify clonal assurance with AI 

With the Cell Metric X series, identify single-cell clones on day 0 with artificial intelligence-based Automated Evidence of Clonality (AEC) and move from testing to IND submission weeks faster.

Demonstrated IND success 

Used by leading pharmaceutical and biopharmaceutical companies and CDMOs worldwide, Cell Metric is the leading solution for compiling evidence of clonality for Investigational New Drug (IND) submissions.  Cell Metric X continues that tradition, with added automation for improved efficiency and data quality.

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The Solentim ecosystem

Workflows for IND success

Assurance of clonality

Evidence that it started as a single cell

Daily whole well imaging

Cell Metric combines high quality images with data continuity, providing daily imaging with recorded evidence of single-cell to clonal growth.

High resolution images ​

Cell Metric combines high quality images with data continuity, providing daily imaging with recorded evidence of single-cell to clonal growth.

FEATURES

Purpose-built for imaging assurance

Right up to the edge

Solid evidence comes from clear single cell images.  Sophisticated methodologies to maintain image clarity right up to the edge.

Always in focus

To manage variation across multi-well plates, proprietary laser focussing ensures optimal focal position in each and every well.

Right up to the edge

Solid evidence comes from clear single cell images. Sophisticated methodologies to maintain image clarity right up to the edge.

Always in focus

To manage variation across multi-well plates, proprietary laser focussing ensures optimal focal position in each and every well.

Clarity in purpose

Designed specifically for the needs of assurance of clonality, Cell Metric has a highly tuned brightfield optical path that maximises the clarity of single-cell imaging for assured cell line development.

Fluorescence imaging for rare event detection

As a tool for workflow verification, Cell Metric offers the option of rapid rare-event fluorescent imaging and reporting.

Clarity in purpose ​

Designed specifically for the needs of assurance of clonality, Cell Metric has a highly tuned brightfield optical path that maximises the clarity of single-cell imaging for assured cell line development.

Fluorescence imaging for rare event detection ​

As a tool for workflow verification, Cell Metric offers the option of rapid rare-event fluorescent imaging and reporting.

Automated confluence determination

For the effective tracking of daily outgrowth, Cell Metric offers automatic measurement and reporting of confluency.

An audit of cell history

Combine data from the entire timeline into a documented clonality report.

Automated confluence determination ​

For the effective tracking of daily outgrowth, Cell Metric offers automatic measurement and reporting of confluency.

An audit of cell history ​

Combine data from the entire timeline into a documented clonality report.

SYSTEMS

Cell Metric series

The trusted standard for clonal assurance

Cell Metric® is a small benchtop high-resolution whole well imaging system developed for cell line development, outgrowth optimisation studies and cell culture processing.  Available as a stand-alone single plate system, or with automated plate handling within a temperature-controlled environment from Cell Metric CLD or downstream third-party robotic integration.  Cell Metric also integrates with the Solentim VIPS™ system via Data Sync system for enhanced laboratory workflows.

Cell Metric series

Cell Metric X series​

Simplify clonal assurance with Artificial Intelligence

Cell Metric® X streamlines and accelerates workflows with superior image resolution, Artificial intelligence (AI) and advanced automation.  The Cell Metric X portfolio includes a 10-position plate stacker, and compatibility with third party robotics. Integration with the STUDIUS™ data management platform and the entire Solentim Ecosystem automates clonality reports and streamlines decision making.

Cell Metric X series

APPLICATIONS

Cell line development

Solentim’s Cell Metric systems enhance the CLD workflow to enable successful IND submissions.  Built to capture solid image-based evidence of assurance, Cell Metric provides unrivalled high clarity whole well imaging.

Single cell cloning
of hiPSCs

CLD for protein therapies

Virus manufacturing for gene therapy

High efficiency, high viability single cell cloning of hiPSCs for applications including development of disease models and supporting GMP manufacture of cell therapies

Generate stable cell lines that create producing novel recombinant proteins such as monoclonal antibodies or therapeutic proteins for rare diseases

From the selection of high producer clones to the development of stable vector producer cell lines, explore our simplified workflows for gene therapy applications

SINGLE CELL CLONING OF hiPSCs​

High efficiency, high viability single cell cloning of hiPSCs for applications including development of disease models and supporting GMP manufacture of cell therapies

CLD FOR PROTEIN THERAPIES​

Generate stable cell lines that create producing novel recombinant proteins such as monoclonal antibodies or therapeutic proteins for rare diseases

VIRUS MANUFACTURING FOR GENE THERAPY​

From the selection of high producer clones to the development of stable vector producer cell lines, explore our simplified workflows for gene therapy applications

Vaccine production using mammalian cells

Engineered exosome producer cell lines

Cell engineering & precision gene editing

Isolate, screen and characterise attributes for clones producing novel recombinant sub-unit protein and monoclonal antibody vaccines

Establish stable producer cells for the production of engineered and cell-engineered exosomes

Optimise your drug discovery process using targeted gene editing to create stable cell lines as cellular reagents, for use in target validation, functional genomics and disease modelling

VACCINE PRODUCTION USING MAMMALIAN CELLS​

Isolate, screen and characterise attributes for clones producing novel recombinant sub-unit protein and monoclonal antibody vaccines

ENGINEERED EXOSOME PRODUCER CELL LINES​

Establish stable producer cells for the production of engineered and cell-engineered exosomes

CELL ENGINEERING & PRECISION GENE EDITING​

Optimise your drug discovery process using targeted gene editing to create stable cell lines as cellular reagents, for use in target validation, functional genomics and disease modelling

APPLICATION notes

Cell Metric reducing the timeline by 30% to produce a monoclonal cell line

VIPS and Cell Metric delivering significant savings for a CDMO

Development of commercial manufacturing cell lines by screening less than 200 clones

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