Solentim

Cell Metric Systems

Benchtop high-resolution whole well imaging

Providing dedicated, purpose-designed, high-resolution whole-well imaging for daily recording of clonal outgrowth in cell line development

The trusted standard for clonal assurance

Cell Metric® is a high contrast imager designed for single cell imaging, identification and clonal outgrowth characterisation.  Cell Metric captures and records crucial evidence, whole well image of the single cell at day 0 and daily imaging thereafter, all wrapped up in a clonality report defining best practice for Master Cell Bank production.

Solid image-based evidence of assurance​

Cell Metric captures a timeline of high quality whole well imaging as solid evidence of clonal origin.  Unmatched high clarity imaging designed for single cell detection, even if the cell is at the wall edge

Save time, resources and financial investment

Such is the confidence in data originating from the Cell Metric, workflows, such as those involving sub-cloning, mini-pools or repeated limited dilution rounds, can be significantly compressed.

Confident submissions with automated clonality report

Cell Metric wraps up the story including imaging, time stamps, annotation and comments as a solid record of evidence ready for confident IND submission.

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Evidence that it started as a single cell

Daily Whole Well Imaging

Cell Metric combines high quality images with data continuity, providing daily imaging with recorded evidence of single-cell to clonal growth.

High Resolution Images

Specialised, high quality images enable the user to observe and clearly annotate single cells. Single cells are discriminated from doublets and wells not containing cells.

Features

Purpose-built for imaging assurance

Right up to the edge

Solid evidence comes from clear single cell images.  Sophisticated methodologies to maintain image clarity right up to the edge.

Clarity in purpose

Designed specifically for the needs of assurance of clonality, Cell Metric has a highly tuned brightfield optical path that maximises the clarity of single-cell imaging for assured cell line development.

Automated confluence determination

For the effective tracking of daily outgrowth, Cell Metric offers automatic measurement and reporting of confluency.

Always in focus

To manage variation across multi-well plates, proprietary laser focussing ensures optimal focal position in each and every well.

Fluorescence imaging for rare event detection

As a tool for workflow verification, Cell Metric offers the option of rapid rare-event fluorescent imaging and reporting.

An audit of cell history

Combine data from the entire timeline into a documented clonality report.

Applications

Cell Line Development

Cell Metric systems are specifically designed for providing monoclonality assurance in cell line development, with high clarity whole well imaging.

Cell line development for biotherapeutics

Generate stable cell lines that create producing novel recombinant proteins such as monoclonal antibodies or therapeutic proteins for rare diseases

Solentim Biologics Manufacture
Solentim Stem Cells hiPSCs

SINGLE CELL CLONING OF hiPSCs

High efficiency, high viability single cell cloning of hiPSCs for applications including development of disease models and supporting GMP manufacture of cell therapies

Virus manufacturing for gene therapy

From the selection of high producer clones to the development of stable vector producer cell lines, explore our simplified workflows for gene therapy applications

Solentim Gene Therapy Vector Manufacture
Solentim Gene Editing

Cell engineering and precision gene editing

Optimise your drug discovery process using targeted gene editing to create stable cell lines as cellular reagents, for use in target validation, functional genomics and disease modelling

Vaccine technology and production with mammalian cells

Isolate, screen and characterise attributes for clones producing novel recombinant sub-unit protein and monoclonal antibody vaccines

Solentim Vaccine Manufacture
3d render of cells secreting exosomes

Engineered exosome producer cell lines

Establish stable producer cells for the production of engineered and cell-engineered exosomes

Systems

Cell Metric

Cell Metric® is a small benchtop high-resolution whole well imaging system developed for cell line development, outgrowth optimisation studies and cell culture processing.  Cell Metric processes a single lidded microtiter plate which then removed and replaced with another one (either by hand or via a robot interface).

Cell Metric CLD

Cell Metric® CLD is our premium version of the Cell Metric with a factory built-in, incubated plate loader for unattended imaging of 10 plates in a cassette.

Cell Metric is part of a portfolio of products along with the VIPS for cell line development.  Once the single cells are in the wells, then Cell Metric can be used to monitor the outgrowth, expansion and other key metrics in making choices of best clones to take forwards.

About Solve Scientific

Solve Scientific caters to the Australian and New Zealand scientific market with high-quality product and innovative technologies. In close partnership with our suppliers our role is delivering premium local support in enabling our customer’s results.

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